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A good spine evaluation distinguishes between these because the treatments are completely different

It may be biochemical, not only structural, in origin

NHS link about consent nhs.uk/tests-and-treatments

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Proc Natl Acad Sci USA 97: 51015106 Tu BP, Weissman JS (2002) The FAD and O(2)dependent reaction cycle of Ero1mediated oxidative protein folding in the endoplasmic reticulum